The MechanoBiology Lab, a BMRC Core Lab directed by Dr. James H-C. Wang, is advancing innovative strategies to prevent overuse tendon injuries.

Recent preclinical research from the lab demonstrates that a topical metformin lotion can prevent the onset of tendinopathy in overused tendons by reducing inflammatory markers and preserving tendon collagen structure, without systemic drug exposure. The study, published in Scientific Reports (2025), shows that localized metformin delivery mitigates inflammation and tissue degeneration while avoiding systemic drug exposure.

Tendinopathy remains a common and challenging condition among athletes, individuals in physically demanding occupations, and military service members, making preventive approaches a critical unmet need.

Because metformin is already FDA-approved for other uses, this work supports rapid translational potential toward human studies in high-risk populations. Ongoing work is focused on formulation optimization, safety studies, and preparation for early-phase human trials.

Learn more about the project:
https://mtec-sc.org/technology-showcase/topical-metformin-lotion-for-tendinopathy-prevention